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Areas of Research:
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Design and synthesis of novel glycosyl donors for highly stereoselective glycosylation reactions.
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Development of organocatalytic methodologies for efficient, metal-free, and sustainable organic transformations.
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Exploration of carbohydrate reactivity and transformations, including selective functionalization and mechanistic studies.
1. Development of sterically hindered salts as organocatalysts
Steric bulk induces unique properties
Space filling model of
protonated TTBPy. Can it behave as a Bronsted-acid?
Behaviour of bulky pyridine salts in non-polar solvents
Poor Ion-pair interactions due to steric bulk
Solvation insusceptibility leads to destablization of the cation
2. A new avenue for secondary amine catalysis-Glycosylation
Our Approach
Glycosylation
Conventional Enamine catalysis
Generation of Oxacarbenium ions
3. Sulfonium salts catalysis Stereoselective 2-Deoxy and Ferrier Glycosylation
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